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1996 Publications

Early exercise testing to stratify risk for development of restenosis after percutaneous transluminal coronary Coplan NL, Curkovic V, Allen KM, Atallah V. - last modified 2013-05-08 10:06
Am Heart J. 1996 Dec;132(6):1222-5.


Restenosis after percutaneous transluminal coronary

angioplasty (PTCA) usually occurs 3 to 6

months after the procedure. The process underlying

restenosis is believed to involve elastic recoil;

platelet accumulation and thrombus formation; release

of platelet-derived growth factors; and fibrocellular

migration and proliferation. Smooth-muscle

proliferation may occur as early as several days

to weeks after PTCA. Thus, to identify effectively

an increased risk for restenosis, a marker must

be present and recognizable early after the procedure.

Studies have shown that clinical and angiographic

variables (recent onset angina, unstable angina,

coronary spasm, anatomic location, nonacute

total occlusions, balloon size, pressure used for inflation,

and intimal dissections) may be used to identify

an increased risk for restenosis. However, no variable

that reliably stratifies risk has been determined.

Early exercise testing after PTCA has been shown

to be safe, but the value of the results for prediction

of later restenosis is variable. This article

evaluates questions about exercise performed early

after PTCA as a method for stratifying risk for restenosis.