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The effect of creatine supplementation on strength recovery after anterior cruciate ligament (ACL) reconstruction: a randomized, placebo-controlled, double-blind trial
by
Tyler TF, Nicholas SJ, Hershman EB, Glace BW, Mullaney MJ, McHugh MP.
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last modified
2009-10-09 15:17
Am J Sports Med. 2004 Mar;32(2):383-8.
BACKGROUND: Creatine supplementation has been shown to augment training-induced
strength gains. The purpose of this study was to examine the effect of creatine
supplementation on recovery of muscle strength after anterior cruciate ligament
(ACL) reconstruction. HYPOTHESIS: Creatine supplementation will facilitate
strength gains after ACL reconstruction. STUDY DESIGN: Double-blind, prospective,
and randomized clinical trial. METHODS: Sixty patients were randomized into
creatine or placebo groups. Quadriceps and hamstring strength and power were
measured isokinetically. Hip flexor, abductor, and adductor strengths were
measured with a handheld dynamometer prior to surgery and at 6 weeks, 12 weeks,
or 6 months after surgery. RESULTS: From 6 weeks to 12 weeks after surgery, there
were significant increases in strength on the involved side for knee extension
(47%), knee flexion (27%), hip flexion (20%), hip abduction (9%), and hip
adduction (17%). These strength improvements were unaffected by creatine
supplementation with similar effects in the creatine and placebo groups. From 6
weeks to 12 weeks after surgery, there were significant increases in power on the
involved side for knee extension (46%) and knee flexion (26%), but these effects
were not affected by creatine supplementation. At 6 months, creatine
supplementation did not affect outcome as measured by the single leg hop test for
distance or the knee outcome score. CONCLUSIONS: The results demonstrate that
patients do not benefit from creatine supplementation during the first 12 weeks
of rehabilitation after ACL reconstruction.